By T.K. Ghose ,A. Fiechter, N.Blakebrough
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Additional info for Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology
Interestingly, the power law model provides an adequate description of rechnical Aspects of the Rheological Properties of Microbial Cultures I00,000 ' • ','"'1 , ' i ',,,"1 i = o Q. v >. 0% tx 5 . 0 % I0,000 A 29 1,000 o[ I00 O. 1 i i iiIlll I i I I Illlal I0 n l I IIIIII IOO I I I II[lll i i iiii 1,000 I0,000 SHEAR RATE ( s- I ) Fig. 20. Viscosity characteristics of culture fluids containing various concentrations of xanthan pseudoplasticity over the shear rate range usually encountered in reactors [20, 57].
The effects of impeller design and aeration are clearly demonstrated. The effect of aeration is particularly noteworthy because the 102 u) v I01 . :E q) Fig. 26. m. NO A I R ~ ~ O ' O - / 5 i J i t,,lll J , ttliNl ,o2 MOMENTUM I ,o 3 FACTOR I 38 M. Charles other available mixing time correlations are based on experiments involving non-gassed fluids. The work of Blakebrough and Sambamurthy suggests that these other correlations should be modified for bio-applications. Finally, it is important to note that the correlation does not include rheological properties explicitly and hence its range of applicability can not be predicted easily.
Tuffile and Pinho  report that for a culture involving S. aureofaciens, the initial medium exhibits pseudoplastic behavior (power law) due to a high starch concentration but that Newtonian behavior develops during the first 22 h as a result of starch hydrolysis. Beyond 22 h mycelial growth causes pseudoplasticity which can be expressed in terms of the power law equation. Typical plots of K and m values as functions of time reaction are given in Fig. 18 . Deindoerfer and West  report that S.
Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology by T.K. Ghose ,A. Fiechter, N.Blakebrough