By P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Priv.-Doz. Dr. W. Hiddemann, Prof. Dr. D. Urbanitz, Prof. Dr. J. Ritter (eds.)
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Extra resources for Acute Leukemias: Prognostic Factors and Treatment Strategies
Williams DL, Tsiatis A, Brodeur GM, Look AT, Melvin SL, Bowman WP, Kalwinksy DK, Rivera G, Dahl GV (1982) Prognostic importance of chromosome number in 136 19 untreated children with acute lymphoblastic leukemia. Blood 60:864-871 18. Barker PE (1982) Double minutes in human tumor cells. Cancer Genet Cytogenet 5:8194 19. Ohyashiki JH, Ohyashiki K, Miller KB, Cuiffo BP, Sandberg AA (submitted) Acute mylomonocytic leukemia with double minute 20 chromosomes and a normal karyotype. Cancer Genet Cytogenet 20.
Similarly, the role of early and late intensification has not been clearly identified. The singlearm studies presented to date have not taken into account the fact that patients who are in continuous complete remission at 1 year (the usual time point selected for late intensification) have a iO-year survival of approximately 50% even without "late intensification" . Ongoing studies of ANLL and related disorders include both clinical studies and laboratory projects to elucidate mechanisms of leukemogenesis and leukemia pathophysiology in an effort to design new therapeutic strategies.
Characterization of Immunologic Subgroups As has already been pointed out, distribution of the different immunologic phenotypes in the F AB subgroups was not at random. Thus, each of the immunologic subgroups was composed of different proportions of morphological types (Table 1). 3") Fig. la, b. Proportions (in percent) of morphological subgroups of a 471 patients with ALL (n = 392) or AUL (n = 79) (FAB classification) and b 334 patients with ALL (n = 288) or AUL (n = 46) Table 1. 4 100 0 3 7 10 The significance of the distribution of the various immunologic groups is as follows: B/L3 vs.
Acute Leukemias: Prognostic Factors and Treatment Strategies by P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Priv.-Doz. Dr. W. Hiddemann, Prof. Dr. D. Urbanitz, Prof. Dr. J. Ritter (eds.)